Kevin P. Campbell, Ph.D. · 2020. 3. 13. · Journal of Comparative Neurology Trends in Neuroscience Journal of Molecular and Cellular Cardiology Trends in Pharmacological Sciences - [PDF Document] (2024)

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• March 2020

  1

  CURRICULUM VITAE

  Kevin P. Campbell, Ph.D.

  Personal Data

  Place of Birth: Brooklyn, New York Citizenship: United StatesMarital Status: Married; Three Children Home Address: 931 EvergreenCourt Iowa City, IA 52245

  Current Position Investigator, Howard Hughes Medical InstituteChair, Department of Molecular Physiology and Biophysics Director,Wellstone Muscular Dystrophy Cooperative Research Center Roy J.Carver Biomedical Research Chair in Molecular Physiology andBiophysics Professor of Neurology University of Iowa Roy J. andLucille A. Carver College of Medicine

  Address: 4283 Carver Biomedical Research Building University ofIowa 285 Newton Road Iowa City, IA 52242-1101 Telephone: (319)335-7867 Cell phone: (319) 594-3283 Fax: (319) 335-6957 Email:[emailprotected] ORCID:http://orcid.org/0000-0003-2066-5889 Web Addresses: Lab:http://www.physiology.uiowa.edu/campbell/ Department:https://medicine.uiowa.edu/physiology/ HHMI:http://www.hhmi.org/research/investigators/campbell_bio.htmlWellstone Muscular Dystrophy Center:https://medicine.uiowa.edu/mdcrc/ Education

  1979 Ph.D. Biophysics, University of Rochester, School ofMedicine & Dentistry, Rochester, New York 1976 M.S. Biophysics,University of Rochester, School of Medicine & Dentistry,Rochester, New York 1973 B.S. Physics, Manhattan College, Bronx,New York Post-Graduate Education 1978-1981 Postdoctoral FellowBanting and Best Department of Medical Research University ofToronto Toronto, Ontario, Canada Advisor: Dr. David MacLennan

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  Academic Appointments

  2005-present Director, Wellstone Muscular Dystrophy SpecializedResearch Center 2005-present Chair & Department ExecutiveOfficer, Department of Molecular Physiology and Biophysics,University of Iowa 2005-present Professor, Department of InternalMedicine, University of Iowa 2002-2005 Interim Department Chair,Department of Physiology and Biophysics, University of Iowa1999-present Carver Trust - Roy J. Carver Biomedical Research Chairin Physiology and Biophysics, University of Iowa 1997-presentProfessor, Department of Neurology, University of Iowa 1989-presentInvestigator, Howard Hughes Medical Institute 1989-1999 Universityof Iowa Foundation Distinguished Professor of Physiology andBiophysics 1988-present Professor, Department of MolecularPhysiology and Biophysics, University of Iowa 1985-1988 AssociateProfessor, Department of Physiology and Biophysics, University ofIowa 1981-1985 Assistant Professor, Department of Physiology andBiophysics, University of Iowa 1978-1981 Postdoctoral Fellow withDr. David MacLennan, Banting and Best Department of MedicalResearch, University of Toronto, Toronto, Ontario, Canada 1976-1978Teaching Assistant, Undergraduate and Graduate Biochemistry,University of Rochester 1973-1977 Graduate Fellow, BiophysicsTraining Grant, Department of Radiation Biology and Biophysics,University of Rochester Honors and Awards 2020 Tamio YamakawaAward, The Japan Consortium for Glycobiology and Glycotechnology2020 Herbert Tabor Research Award, American Society forBiochemistry and Molecular Biology 2017 Society for GlycobiologyPresident’s Innovator Award 2017 UI Senior Student Recognition List2016 Lifetime Achievement Fellow, American Society for Cell Biology2016 Greg Marzolf, Jr. Foundation Symposium Visiting Lecture Award2016 UI Senior Student Recognition List 2015 Inaugural Fellow,American Physiological Society 2014 UI Senior Student RecognitionList 2010 A. Ross McIntyre Award 2009 March of Dimes Prize inDevelopmental Biology 2007 Presidential Lecturer, The University ofIowa 2006 American Academy of Arts and Sciences 2005 Carver Collegeof Medicine Distinguished Mentor Award 2004 National Academy ofSciences 2004 American Academy of Microbiology 2004 AmericanAcademy of Neurology Lecturer Award 2004 Rochester DistinguishedScholar Award 2003 University of Manitoba Samuel WeinerDistinguished Visitor Award 2001 Elsevier Science Award at theWorld Muscle Society Meeting 2001 S. Mouchly Small, MDA ScientificAchievement Award 2001 Weil Award for Best Paper in ExperimentalNeuropathology 2000 G. Conte Prize 2000 for Basic Research 1999National Academy of Medicine (formerly Institute of Medicine) ofthe National Academy of Sciences 1999 Carver Trust - Roy J. CarverBiomedical Research Chair in Molecular Physiology and Biophysics1999 Fellow of the Biophysical Society 1997 duch*enne-Erb-PreisAward (German Muscular Dystrophy Association) 1996 Esther BenjaminMemorial Lecture Award 1996 Landacre Society Lecture Award 1996American Academy of Neurology Decade of the Brain Award 1995INSERM/Académie des Sciences Prix 1994 McGill University F.L.McNaughton Lecturer

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  1994 Vanderbilt University 1994 Lamson Memorial Lecturer 1994ASBMB-AMGEN Award 1994 International Albrecht Fleckenstein Award1993 Muscular Dystrophy Association Service Merchandise LeadershipAward 1992 The Emilio Trabucchi Foundation Medal 1989 Howard HughesMedical Institute Investigator 1989 University of Iowa FoundationDistinguished Professor of Physiology and Biophysics 1990 Regent'sAward for Faculty Excellence 1984 Finalist for 1984 Louis N. KatzResearch Prize for Young Investigators 1984-1989 American HeartAssociation Established Investigator 1978 National ScienceFoundation - NATO Postdoctoral Fellowship 1978-1981 MedicalResearch Council of Canada Postdoctoral Fellowship 1977-1978 ElonHuntington Hooker Fellowship 1974-1977 Graduate Fellowship - NIHBiophysics Training Grant 1973 Sigma Pi Sigma Bendix Award 1973 PhiBeta Kappa 1972 Sigma Xi

  Professional Activities Affiliations

  American Academy of Arts and Sciences Biophysical SocietyAmerican Academy of Neurology National Academy of Medicine,National Academy of Sciences American Association for Advancementof Science National Academy of Sciences American Chemical SocietyNew York Academy of Sciences American Society for Biology andMolecular Biology Society for Developmental Biology AmericanSociety of Biological Chemistry Society For Glycobiology AmericanSociety for Cell Biology Society for Neuroscience American Societyfor Gene Therapy Society of General Physiologists American Societyof Human Genetics Sigma Xi American Society for Matrix BiologyAmerican Society for Microbiology

  World Muscle Society

  American Physiological Society Editorial Boards 2010-presentSkeletal Muscle, Founding Co-Editor-in-Chief 2013-present Journalof Neuromuscular Diseases 2012-present Experimental Neurology2011-present PLoS Currents: Muscular Dystrophy 2004-presentNeuromuscular Disorders 2004-2006 Molecular and CellularBiochemistry 2003-2006 Drug Discovery Today: Therapeutic Strategies2002-2006 NeuroMolecular Medicine 2001-present Acta Myologica2001-2004 American Society for Biochemistry and Molecular Biology1999-2004 Journal of Cell Biology 1996-2001 Journal of BiologicalChemistry 1995-1997 Physiological Reviews 1988-1993 Cell Calcium1988-1993 Journal of Biological Chemistry 1987-1993 CirculationResearch

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  Reviewer (Journals)

  Acta Neuropathologica Journal of Neuroscience American Journalof Human Genetics Journal of Neuropathology and ExperimentalNeurology American Journal of Pathology Journal of the NeurologicalSciences American Journal of Physiology Journal of PhysiologyAnnals of Neurology Matrix Biology Archives of Biochemistry andBiophysics Molecular and Cellular Biology Biochimica et BiophysicaActa Molecular and Cellular Neuroscience BioMed Central MolecularBiology of the Cell Biophysical Journal Molecular Brain ResearchCardiovascular Research Molecular Pharmaceutics Cell MolecularPharmacology Cell Metabolism Molecular Therapy Circulation NatureCirculation Research Nature Cell Biology Current Biology NatureGenetics Development Nature Medicine Developmental Biology NatureNeuroscience Developmental Cell Nature Review Molecular CellBiology eLife Neurobiology of Disease EMBO Molecular MedicineNeurogenetics European Journal of Human Genetics Neurology FASEBNeuromuscular Disorders FEBS Neuron FEBS Letters NeuroscienceGenome Research New England Journal of Medicine Glycobiology PLoSMedicine Human Gene Therapy PLoS ONE Human Molecular GeneticsProceedings of the National Academy of Science Journal ofBiological Chemistry Science Journal of Cell Biology ScienceTranslational Medicine Journal of Cell Science Stem Cell Journal ofClinical Investigation Traffic Journal of Comparative NeurologyTrends in Neuroscience Journal of Molecular and Cellular CardiologyTrends in Pharmacological Sciences Journal of NeurochemistryVirology

  Reviewer (Grants) 2017-present Coalition to Cure Calpain 32013-present Reviewer, HHMI Medical Fellows Program Group 2008Inserm, Myology Lab Site Visit (Paris, France) 2005-2007 CouncilMember, National Arthritis and Musculoskeletal and Skin DiseaseAdvisory Council 2003 March of Dimes Grant Reviews 2001-2005 NIHSkeletal Muscle Biology and Exercise Physiology Study Section 1999NIH, Grant Reviews 1996-2009 Member, MDA Scientific AdvisoryCommittee 1992 NIH, Site Visit (Indiana University) 1991-1995 NIH,Physiology Study Section 1989-1995 Member, MDA Fellowship ReviewCommittee 1989-1992 Member, AHA’s Cell Transport and MetabolismResearch Study Committee 1988 NIH, Site Visit (University of Miami)1987 NIH, Site Visit (University of Washington)

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  1986 NIH, NIADDK Conference Grant 1986 Member, NSF -Presidential Young Investigator Advisory Panel 1985-1988 Member,Research Peer Review Committee, AHA - Iowa Affiliate National &International Committees 2019-present Member, ASBMB AwardsCommittee 2015-present Scientific Advisory Board, Spinal MuscularAtrophy Foundation 2013-present Member, Committee on Honors,American Physiological Society 2011-present Vanderbilt Prize inBiomedical Science External Review Committee 2010-present T32External Networking Committee, The Ohio State University2010-present Member, Biomedical Science Advisory Board, VanderbiltUniversity 2009-present Scientific Advisor, Gavriel Meir Trust2006-2010 Scientific Advisory Board Committee, Duke NUS-GraduateMedical School, Singapore 2004-present Scientific Advisory Board,Cure duch*enne 2004-2005 President, Society of General Physiologists2003-2006 Council Member, American Society of Matrix Biology2001-2004 Pharmaceutical Research, MyoContract 2001-2003 NIHSkeletal Muscle Biology Study Section 2001-2006 Member, ExecutiveBoard of the World Muscle Society 1998-2004 Member, MuscularDystrophy Association’s Gene Therapy Task Force 1997 SteeringCommittee for Huntington’s Disease Society of America 1993-1995Council Member, Society of General Physiologists 1988-1991 Officerof the Biophysical Society Council University Committees andPrograms 2019-present Steering Committee, UI Strategic PlanningProcess 2018-present UI Health Care System Operations Committee2018-2019 Micro/Immuno Chair Search Committee 2018-presentEnterprise Committee 2018-present Finance Subcommittee 2018-presentFunds Flow Working Group 2015-present Chair, Carver College ofMedicine Research Investment Fund Committee 2000-present Member,Holden Comprehensive Cancer Center 2011-2012 Search Committee forthe Dean of the Carver College of Medicine 2009-2011 Carver Collegeof Medicine Research Advisory Council 2009-2010 Internal AdvisoryCommittee on Genetics for the Carver College of Medicine 2008-2009Animal Care Facilities Planning Task Force 2007 IntercollegiateTask Force on the Organization of Research and Education in theLife Sciences 2007-2012 Office of Animal Resources AdvisoryCommittee 2006 Distinguished Mentor Nomination Committee 2003Holden Comprehensive Cancer Center Space Committee 2003-2008Molecular Biology Executive Committee 2003-2004 Steering Committee,Presidential Biological Scholar Program 2003-2004 Search Committeefor Department Executive Officer, Department of Internal Medicine2002-2009 Executive Committee, Neuroscience Program 2002-presentMedical Council 2001-present University of Iowa Gene Therapy CenterProgram Member 2001-present University of Iowa Cancer CenterProgram Member 2001-2005 Curriculum Committee, Neuroscience Program2000-2004 College of Medicine Molecular Biology Building B PlanningCommittee 2000-2002 Task Force on Animal Imaging

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  1997-2006 Member, Neuromuscular Disease Conference 1997 MedicalScientist Training Program Review Committee 1996-present DiabetesEndocrinology Research Center Program Member 1996-2003 College ofMedicine Capital Planning Liaison Committee 1995-2005 Howard HughesMedical Institute, College of Medicine Seminar Series 1995-2003College of Medicine Research Advisory Council 1995-2000 College ofMedicine Research Week Committee 1995-2000 Hybridoma FacilityAdvisory Committee 1995-1996 Search Committee for DepartmentExecutive Officer, Department of Biochemistry 1994-1999 Committeefor the Initiative in the Biosciences 1994-1995 Search Committeefor Associate Dean for Research, College of Medicine 1993-presentExecutive Committee of the Cardiovascular Center 1993-1994 ReviewCommittee for Vice President for Research 1991-1994 SearchCommittee for the Dean of the College of Medicine 1990-1991Microbiology Review and Search Committee for Department ExecutiveOfficer 1990 Radiation Research Laboratory Review Committee1989-1992 Medical Bio-Science Subcommittee of the UniversityRadiation Protection Committee 1988-1992 AHA Medical StudentResearch Fellowship Program Selection Committee 1987-presentUniversity of Iowa Medical Scientist Training Program FacultyMentor 1986-1989 College of Medicine Research CommitteeDepartmental Committees 1995 Co-Chairman, Physiology and BiophysicsComputer Committee 1993 Chairman, Dr. Charles Wunder Review 1991Physiology and Biophysics Faculty Search Committee 1990 Chairman,Neuroscience Workshop 1989-1990 Chairman, Physiology and BiophysicsFaculty Search Committee 1989-2002 Chairman, Physiology Workshop1987-2002 Departmental Executive Committee 1986-1987 Chairman,Physiology and Biophysics Seminar Committee 1984-1986 Physiologyand Biophysics Computer Committee 1983-1986 Chairman, Physiologyand Biophysics Graduate Admissions Committee 1982-1986 Chairman,Physiology and Biophysics Graduate Recruiting Poster Committee1982-1986 Physiology and Biophysics Graduate Admissions Committee1982-1984 Physiology and Biophysics Equipment User Committee1981-1983 Physiology and Biophysics Faculty Search CommitteeReviews of Academic Departments and Centers 2013 VanderbiltWellstone Scientific Advisory Committee Review of VanderbiltUniversity’s Paul and Sheila Wellstone Muscular Dystrophy Center2010-present Vanderbilt Biomedical Science Advisory Board Review ofthe Vanderbilt University School of Medicine 2006-2011 Duke-NUSGraduate Medical School, Singapore Scientific Advisory Board Reviewof the University of Duke University Graduate Medical School,Singapore 2005-2009 Minnesota Wellstone Scientific AdvisoryCommittee Review of the University of Minnesota’s Paul and SheilaWellstone Muscular Dystrophy Center 2005 University of PennsylvaniaSchool of Medicine

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  Review of the University of Pennsylvania School of MedicineDepartment of Physiology 2004 Duke University Review of the DukeUniversity School of Medicine Department of Cell BiologyOrganization of Scientific Meetings 2009-present Organizer, IowaWellstone Face-to-Face Meeting, University of Iowa Wellstone MDCenter 2008 Organizer and Session Chair, Iowa Congenital MuscularDystrophy Meeting, University of Iowa

  Wellstone MD Center 2007 Organizer, Congenital MuscularDystrophy and Dystroglycan Glycosylation Meeting, World Muscle

  Society 2006 Organizer, Frontiers in Myogenesis Meeting, Societyfor Muscle Biology 2004 Organizer, College of Medicine/HHMI SeminarSeries Rosela Tupler, John Faulkner, Hannele Ruohola-Baker, JeffreyMolkentin, James Ervasti, Gregory Cox 2003 Organizer, College ofMedicine/HHMI Seminar Series David J. Glass, Stuart Kornfeld,Ulrich Mueller, Guilio Cossu, Yukio f*ckuyama, Francesco Muntoni,Peter Agre, Anton Bennett and Joshua Sanes 2002 Organizer, Collegeof Medicine/HHMI Seminar Series Luis Parada, Martin Chalfie, SriramSubramaniam, Anthony Wynshaw-Boris and Yukiko Goda 2001 Organizer,College of Medicine/HHMI Seminar Series Wolfhard Almers, PietroDeCamilli, Brian Duling and Steven Burden 2000 Organizer, Collegeof Medicine/HHMI Seminar Series Morgan Sheng, Susan McConnell,Richard Scheller and Thomas Südhof 1999 Organizer, College ofMedicine/HHMI Symposium, Phenotypic Analysis of GeneticallyEngineered Mice:

  Insights to Biology and Human Disease Sally Camper, MarioCapecchi, William Dove, Reinhard Fassler and Joseph Takahashi 1998Organizer, Carver Symposium, The Molecular Basis of NeurogeneticDiseases Xandra Breakfield, Kay Davies, Kurt Fischbeck, UlrikeHeberlein, Erik Kandel, David MacLennan, Jeffrey Noebels, MihaelPolymeropoulous, Dennis Selkoe, Chris Walsh, Steve Warren and HudaZoghbi 1997 Organizer, College of Medicine Research Week, CancerBiology: Molecular and Genetic Approaches Wen-Hwa Lee, Erkki I.Ruoslahti, Ayraham Raz, Mina J. Bissell and Carlo Croce 1996Organizer and Chair, College of Medicine/HHMI Symposium,Cell-Extracellular Matrix Interactions in

  Development and Disease Angela Christiano, David Cheresh, BrigidHogan, James Kramer and Louis Reichardt 1996 Organizer and Chair,College of Medicine Research Week, Neurobiology: Molecular, Geneticand

  Clinical Approaches Robert H. Brown, Antonio R. Damasio, Ted M.Dawson, Story C. Landis and Katherine Kalil 1992 Chairperson andOrganizer, FASEB Conference, Calcium and Cell Function

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  1989 Co-Chair, FASEB Conference, Calcium and Cell FunctionScientific Advisory Boards & Consulting 2019-present VertexPharmaceuticals, Inc. Scientific Advisory Board 2019-present AmicusTherapeutics, Inc. Consultant 2019 Walking Fish Therapeutics Inc.Consultant 2018 TREAT-NMD Advisory Committee for Therapeutics(TACT) Consultant 2018-present Satellos Bioscience Consultant2017-2018 Audentes Therapeutics, Inc. Consultant 2017-2019 MNGLaboratories Scientific Advisory Board 2015-2018 Spinal MuscularAtrophy Foundation Scientific Advisory Board 2013-2015 GenzymeCorporation Scientific Advisory Board 2010-present Coalition toCure Calpain 3 Consultant 2010-2011 NGM Biopharmaceuticals, Inc.Consultant 2010-2011 Five Prime Therapeutics, Inc. Consultant2010-2011 Eleven Biotherapeutics Consultant 2010-2018 The duch*enneResearch Fund Scientific Advisory Board 2010-present VanderbiltUniversity Biomedical Science Advisory Board 2008-2012 ARMGOPharmaceutical, Inc. Scientific Advisory Board 2006-2010 Duke NUSGraduate Medical School Singapore Scientific Advisory BoardCommittee 2004-present Cure duch*enne Scientific Advisory Board2001-2004 MyoContract Pharmaceutical Research (Basel,Switzerland)

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  Teaching Activities University of Iowa

  Course Title Course No. Year(s) Registered Effort NeuromuscularDiseases: Case-Based Seminar 1997-current Human Organ Systems140:250 1996-2012 200 15 % Medical Cell Biology 60:116 1996-2012200 5 % Human Physiology for PA Students 72:164 2002-2008 40 5 %Survival Skills for a Research Career 060:204 2000-2006 150 5 %Mini Medical School Lecture, April 10, 2007 n/a 2007 200 5%Neurobiology of Disease 132:235:001 2006 25 5% ExperimentalApproaches to Human Disease 060:208 2001-04 20 5 % FundamentalNeuroscience 132:180 2000 20 5 % Principles of Molecular and CellBiology (Facilitator) 156:201 2000-02 80 5 % Medical Neuroscience72:234 1992 200 5 % Medical Neuroscience, Course Co-Director 72:2341991 200 5 % Neuroscience Seminar 132:265 1990-91 14 100 % CellBiology II 142:255 1990 15 30 % Medical Physiology, Course Director72:212 1988-90 190 30 % Membrane Seminar 72:255 1984-89 10 100 %Intermediate Physiology 72:150 1983-84 235 15 % Graduate Physiology72:214 1983-84 8 15 % Medical Physiology 72:212 1982-95 190 20 %Structure and Function of Biological Membranes 72:241 1982-92 10100 % Advanced Biomedical Studies 50:198 1982 10 10 % Cell Biology72:111 1981 10 10 %

  International Teaching Positions January 2006 Masters Class inMolecular Mechanisms of Disease Glycogenetics and NeuromuscularDiseases Nijmegen School of Molecular Life Sciences (NCMLS)Nijmegen, The Netherlands Personal Statement

  My laboratory is focused on understanding the molecular,cellular and physiological basis of various forms of musculardystrophy, and on developing therapeutic strategies to treat thesediseases. My early studies at the University of Iowa focused onelucidating the structure and function of calcium channels andcalcium release channels (ryanodine receptors) in skeletal muscle.For the past twenty years, however, my laboratory has activelyinvestigated the molecular pathogenesis of muscular dystrophy. Wehave used biochemical, cell biological, genetic and physiologicaltechniques to identify and define disease mechanisms that causevarious forms of muscular dystrophy. We cloned and characterizeddystroglycan, and demonstrated that it links the cytoskeleton tothe extracellular matrix in skeletal muscle. My studies ondystroglycan have since led to significant insights into its basicfunction as an extracellular matrix receptor in skeletal muscle,its role in the maintenance of muscle-cell membrane integrity andits role in the molecular pathogenesis of glycosylation-deficientmuscular dystrophy. As head of the laboratory, I have beendedicated to maintaining the highest standards in research andproviding outstanding research training and mentorship for manyundergraduates, graduate students, and postdoctoral and clinicalfellows at the University of Iowa. Many of my former trainees haveembarked on promising research and clinical careers and are nowleaders in the fields of physiology, neurology, molecular genetics,and cellular biology.

  Research and Training

  1. Skeletal muscle excitation-contraction coupling and calciumchannels Muscle contraction is initiated by a depolarization of thetransverse tubular membrane which in turn signals the release ofCa2+ from the junctional sarcoplasmic reticulum. One goal of myearly research was to understand the structure and

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  function of protein components of the junctional sarcoplasmicreticulum membrane. We purified the ryanodine receptor of rabbitmuscle sarcoplasmic reticulum and showed that it can mediate singlechannel activity identical to that of the Ca2+ release channels ofthe sarcoplasmic reticulum. The morphology of the purifiedryanodine receptor has revealed that the ryanodine receptor isidentical to the “SR feet” and thus indicates that it plays a dualrole in excitation-contraction coupling as the Ca2+ release channeland as the bridging structure in the junctional gap. A second goalof my research on excitation-contraction coupling concerned thedihydropyridine-sensitive Ca2+ channel of skeletal muscle and itsdual role as a voltage sensor for excitation-contraction couplingand a Ca2+ channel. The dihydropyridine receptor was purified fromrabbit skeletal muscle and shown to consist of four subunits (α1,α2δ, β and γ). We have determined the structure of the α2δ subunitand γ-subunit of the dihydropyridine receptor. We demonstrated thatthe β-subunit binds to a conserved domain within the α1 subunit ofthe calcium channel. Mutations within conserved domain alter thecharacteristic current stimulation and kinetic changes induced bythe β-subunit and hence identify the critical importance of thisinteraction site in calcium channel regulation. • Jay, SD, Ellis,SB, McCue, AF, Williams, ME, Vedvick, TS, Harpold, MM and Campbell,KP. (1990) Primary

  Structure of the γ Subunit of the DHP-Sensitive Calcium Channelfrom Skeletal Muscle. Science 248:490-492. PMID: 2158672 (Cited 274times)

  • De Waard, M, Pragnell, M and Campbell, KP. (1994) Ca2+ ChannelRegulation by a Conserved β Subunit Domain. Neuron 13:495-503.PMID: 8060623 (Cited 286 times)

  • Pragnell, M, De Waard, M, Mori, Y, Tanabe, T, Snutch, TP andCampbell, KP. (1994) Calcium Channel β Subunit Binds to a ConservedMotif in the I-II Cytoplasmic Linker of the α1-Subunit. Nature368:67-70. PMID: 7509046 (Cited 640 times)

  • Gurnett, CA, De Waard, M and Campbell, KP. (1996) DualFunction of the Voltage-Dependent Ca2+ Channel α2δ Subunit inCurrent Stimulation and Subunit Interaction. Neuron 16:431-440.PMID: 8789958 (Cited 285 times)

  2. Dystrophin-glycoprotein complex

  In 1989 I began a series of experiments aimed at identifyingmembrane proteins that associate with dystrophin—the proteinencoded by the duch*enne muscular dystrophy (DMD) gene—in order tounderstand its function in normal skeletal muscle. Using bothbiochemistry and molecular biology, I discovered thedystrophin-glycoprotein complex and established that it isessential for linking dystrophin (and thereby the cytoskeleton) tothe extracellular matrix in skeletal muscle, and thereby protectsthe muscle-cell membrane from contraction-induced injury.Subsequent studies by my laboratory and others showed thatmutations in genes encoding various components of thedystrophin-glycoprotein complex cause distinct forms of limb-girdlemuscular dystrophy, as well as other congenital forms of musculardystrophy.

  • Campbell, KP and Kahl, SD. (1989) Association of Dystrophinand an Integral Membrane Glycoprotein. Nature

  338:259-262. PMID: 2493582 (Cited 545 times) • Ervasti, JM,Ohlendieck, K, Kahl, SD, Gaver, M and Campbell, KP. (1990)Deficiency of a Glycoprotein Component

  of the Dystrophin Complex in Dystrophic Muscle. Nature345:315-319. PMID: 2188135 (Cited 931 times) • Ervasti, JM andCampbell, KP. (1991) Membrane Organization of theDystrophin-Glycoprotein Complex. Cell

  66:1121-1131. PMID: 1913804 (Cited 1269 times) • Matsumura, K,Tomé, FMS, Collin, H, Azibi, K, Chaouch, M, Kaplan, J-C, Fardeau,M, and Campbell, KP. (1992)

  Deficiency of the 50K Dystrophin-Associated Glycoprotein inSevere Childhood Autosomal Recessive Muscular Dystrophy. Nature359:320-2. PMID: 1406935 (Cited 297 times)

  3. Dystroglycan: Novel extracellular matrix receptor.

  In 1992, my laboratory cloned dystroglycan and elucidated itsfunction as an extracellular matrix receptor in muscle. Weestablished that dystroglycan serves as an essential structurallink between the cytoskeleton and the basem*nt membrane thatsurrounds the cell, and that disruption of its expression and/orability to interact with these structures is responsible for thepathogenesis of duch*enne muscular dystrophy. Although dystroglycanhas been studied extensively, as late as 2011 no patient mutationhad been identified in the encoding gene (DAG1). At that point, mylaboratory identified a dystroglycan missense mutation in a patientwith mild muscular dystrophy accompanied by cognitive impairment.Interestingly, the missense mutation in DAG1 leads to selectiveimpairment of LARGE-mediated functional modification of thephosphorylated O-mannosyl residues on dystroglycan (i.e., thatrequired for high-affinity laminin binding). Overall, mylaboratory’s studies revealed that the T192M substitution in mouserecapitulates both the biochemical and pathological phenotypes ofpatients with dystroglycanopathies, even though all of theglycosyltransferases are normally expressed. •Ibraghimov-Beskrovnaya, O, Ervasti, JM, Leveille, CJ, Slaughter,CA, Sernett, SW, and Campbell, KP. (1992)

  Primary Structure of Dystrophin-Associated Glycoproteins LinkingDystrophin to the Extracellular Matrix. Nature 355:696-702. PMID:1741056 (Cited 1304 times)

  • Ervasti, JM and Campbell, KP. (1993) A Role for theDystrophin-Glycoprotein Complex as a Transmembrane Linker BetweenLaminin and Actin. J. Cell Biol. 122:809-23. PMID: 8349731 (Cited1216 times)

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  • Henry, MD and Campbell, KP. (1998) A Role for Dystroglycan inBasem*nt Membrane Assembly. Cell. 95:859-70. PMID: 9865703 (Cited368 times)

  • Hara, Y, Balci, B, Kanagawa, M, Beltran-Valero de Bernabe, D,Gundesli, H, Yoshida-Moriguchi, T, Willer, T, Satz, JS, Burden, SJ,Oldstone, MBA, Accardi, A, Talim, B, Muntoni, F, Topaloglu, H,Dincer, P and Campbell, KP. (2011) A Dystroglycan MutationAssociated with Limb-Girdle Muscular Dystrophy. N. Eng. J. Med.364: 939-46. PMID: 21388311; PMC3071687 (Cited 172 times)

  4. Disruption of the post-translational processing ofdystroglycan and congenital muscular dystrophies

  In 2002, we found that O-linked glycosylation of α-dystroglycanis required for its binding to extracellular matrix ligands andthat abnormal post-translational processing of α-dystroglycanresults in loss of its function as an extracellular matrix receptorin various congenital muscular dystrophies. We demonstrated thatglycosylation defects in dystroglycan are central to the skeletalmuscle pathology and the developmental brain abnormalities seen incongenital muscular dystrophies including Walker-Warburg syndrome,muscle-eye-brain disease and f*ckuyama congenital musculardystrophy. Overall, this research has revolutionized ourunderstanding of the molecular basis of these devastating diseasesand has profound clinical implications for the diagnosis andtreatment of congenital muscular dystrophies with developmentalbrain abnormalities.

  • Michele, DE, Barresi, R, Kanagawa, M, Saito, F, Cohn, RD,Satz, JS, Dollar, H, Nishino, I,

  Kelley, RI, Somer, H, Straub, V, Mathews, KD, Moore, SA andCampbell, KP. (2002) Post-translational Disruption ofDystroglycan-Ligand Interactions in Congenital MuscularDystrophies. Nature 418:417-422. PMID: 12140558 (Cited 704times)

  • Moore, SA, Saito, F, Chen, J, Michele, DE, Henry, MD, Messing,A, Cohn, RD, Ross-Barta, SE, Westra, S, Williamson, RA, Hoshi, T,Campbell, KP. (2002) Deletion of Brain Dystroglycan RecapitulatesAspects of Congenital Muscular Dystrophy. Nature 418:422-5. PMID:12140559 (Cited 482 times)

  • Barresi, R, Michele, DE, Kanagawa, M, Harper, HA, Dovico, SA,Satz, JS, Moore, SA, Zhang, W, Schachter, H, Dumanski, JP, Cohn,RD, Nishino, I and Campbell, KP. (2004) LARGE Can FunctionallyBypass α-Dystroglycan Glycosylation Defects in Distinct CongenitalMuscular Dystrophies. Nat. Med. 10:696-703. PMID: 15184894 (Cited246 times)

  • Kanagawa, M, Saito, F, Kunz, S, Yoshida-Moriguchi, T, Barresi,R, Kobayashi, YM, Muschler, J, Dumanski, JP, Michele, DE, Oldstone,MB and Campbell, KP. (2004) Molecular Recognition by LARGE isEssential for Expression of Functional Dystroglycan. Cell117:953-64. PMID: 15210115 (Cited 230 times)

  5. LARGE modification of dystroglycan

  Despite extensive efforts—by several groups and over the courseof nearly twenty years—to identify the laminin-binding moiety onalpha-dystroglycan, its identity remained a mystery. At least 17gene products, many of which are glycosyltransferases, are involvedin biosynthesis of the functional alpha-dystroglycan modification.In 2010, we discovered that this modification is initiated by aunique O-linked trisaccharide, GalNAc-β1,3-GlcNAc-β1,4-Man-Ser/Thr,which is phosphorylated at position 6 of the mannose residue. Thisphosphorylated trisaccharide is required for laminin binding, viaan unknown mechanism. In 2012, we showed that the bifunctionallike-acetylglucosaminyltransferase (LARGE) synthesizes apolysaccharide that is comprised of alternating glucuronic acid(GlcA) and xylose (Xyl) residues. The LARGE-synthesized[-GlcA-β1,3-Xyl-α1,3-]n heteropolysaccharide (termed matriglycan)was shown bind LG domain-containing proteins in vitro. We alsodemonstrated that LARGE glycans on dystroglycan function as atunable matrix scaffold to prevent dystrophy. These findings led usto propose that the ultrastructural organization of the basem*ntmembrane can be modified by extension of the LARGE-glycan. Ourfindings both redefine the cellular significance of dystroglycanand support a new model for the underpinnings ofdystroglycan-related disease. Most recently, Dr. Campbell used amultidisciplinary approach to determine the structural basis of thehigh-affinity binding of laminin to dystroglycan. Crystalstructures of the laminin LG4-5 region in complex with aLARGE-synthesized oligosaccharide revealed an unprecedentedmechanism of carbohydrate recognition among animal lectins: oneGlcA-β1,3-Xyl disaccharide unit straddles a calcium ion in the LG4domain, with oxygen atoms from both sugars replacing calcium-boundwater molecules. This chelating binding mode accounts for theunusually high affinity of this protein-carbohydrateinteraction.

  • Yoshida-Moriguchi, T, Yu, L, Stalnaker, SH, Davis, S, Kunz, S,Oldstone, MBA, Schachter, H, Wells, L and

  Campbell, KP. (2010) O-Mannosyl Phosphorylation ofAlpha-Dystroglycan is Required for Laminin Binding. Science327:88-92. PMID: 20044576; PMC2978000 (Cited 272 times)

  • Inamori, K, Yoshida-Moriguchi, T, Hara, Y, Anderson, ME, Yu, Land Campbell, KP. (2012) Dystroglycan Function Requires Xylosyl-and Glucuronyltransferase Activities of LARGE. Science 335: 93-96.PMID: 22223806; PMC3702376 (Cited 171 times)

  • Yoshida-Moriguchi, T, Willer, T, Anderson, ME, Venzke, D,Whyte, T, Muntoni, F, Lee, H, Nelson, SF, Yu, L., Campbell, KP.(2013). SGK196 is a Glycosylation-Specific O-Mannose KinaseRequired for Dystroglycan Function. Science 341: 896-9. PMID:23929950; PMC3848040 (Cited 106 times)

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  • Goddeeris, MM, Wu, B, Venzke, D, Yoshida-Moriguchi, T, Saito,F, Matsumura, K, Moore, SA, Campbell, KP. (2013) Large Glycans onDystroglycan Function as a Tunable Matrix Scaffold to PreventDystrophy. Nature 503: 136-40. PMID: 24132234; PMC3891507 (Cited 49times)

  • Briggs, D., Yoshida-Moriguchi, T., Zheng, T., Venzke, D.,Anderson, M., Strazzulli, A., Moracci, M., Yu, L., Hohenester, E.,Campbell, KP. Structural Basis of Laminin Binding to the LARGEGlycans on Dystroglycan. Nat Chem Biol. 2016 Oct; 12(10):810-814.PMID: 27526028; PMC5030134 (Cited 9 times)

• 13

  Graduate Students

  Name and Degree Current Employment Organization Current TitleJyothi Arikkath, Ph.D. (1997-2002)

  Munroe-Meyer Institute for Genetics and Rehabilitation,Department of Developmental Neurology, University of NebraskaMedical Center

  Assistant Professor

  Dimple Bansal, Ph.D. (1998-2003)

  Biocon, Oncology Business Unit, Bangalore, India

  Head of Marketing and Strategy

  Wei Guo, Ph.D. (1992-1995)

  University of Pennsylvania, Department of Biology, Philadelphia,PA

  Professor

  Christina Gurnett, M.D./Ph.D. (1992-1997)

  Washington University School of Medicine, Department ofNeurology, Division of Pediatric and Developmental Neurology, St.Louis, MO

  Professor, Director, Division of Pediatric and DevelopmentalNeurology

  Scott Jay, M.D./Ph.D. (1984-1991)

  Wellmont CVA Heart Institute: Laughlin Campus, Greeneville,TN

  Staff Cardiologist

  Myoung-Goo Kang, Ph.D. (1998-2003)

  Institute for Basic Science, Center for Cognition and Sociality,Daejeon, Korea University of Texas Medical Branch, Galveston,TX

  Principal Investigator and Adjunct Faculty

  Michael Knudson, M.D./Ph.D. (1985-1992)

  University of Iowa, Department of Pathology, Iowa City, IA

  Clinical Professor

  See Also

  2015 International Car Rental Show Attendee Roster as of ... · PDF fileGuy Higbey Bandago San Francisco CA USA Sharky Laguana Bandago Van Rental San Francisco CA USA ... Benjamin - [PDF Document]

  Albert T. Leung, M.D./Ph.D. (1986-1989)

  New York, NY Independent Clinical Science Consultant

  Leland Lim, M.D./Ph.D. (1993-1999)

  Stanford University School of Medicine and Veterans Affairs PaloAlto Healthcare System, Department of Neurology, Palo Alto, CA

  Staff Physician and Clinical Assistant Professor

  Hongyan Liu, Ph.D. (1992-1997)

  New York, NY Homemaker

  David R. Pepper, M.S./M.D. (1984-1986)

  Contra Costa Regional Medical Center, Martinez, CA; UCSD,Department of Family and Community Medicine, San Francisco, CA

  Family Medicine Physician and Assistant Clinical Professor

  Peter McPherson, Ph.D. (1988-1993)

  McGill University, Department of Neurology, Neurosurgery, andAnatomy and Cell Biology; Montreal Neurological Institute; MontrealNeurological Institute, Montreal, Canada

  James McGill Chair and Director, Neurodegenerative DiseaseResearch Group

  Marlon Pragnell, Ph.D. (1990-1994)

  Juvenile Diabetes Research Foundation New York, NY

  Senior Scientific Program Manager

  Jakob Satz, Ph.D. (1999-2007)

  Jackson Laboratories, Bar Harbor, ME Postdoctoral Fellow

• 14

  Alan H. Sharp, Ph.D. (1983-1988)

  Alan Sharp Pty Ltd, Victoria, Australia Physician, Allergy andClinical Immunology Specialist

  Bin Yang, Ph.D. (1991-1995)

  Genentech, Inc./Roche San Francisco, CA

  Scientist/Group Leader

  Postdoctoral Fellows

  Name and Degree Current Employment Organization CurrentTitle

  Valerie Allamand, Ph.D. (1996-2000)

  INSERM Institut de Myologie, Center for Research in Myology,Paris, France

  Group Leader

  Rita Barresi, Ph.D. (1998-2006)

  NSCT Diagnostic & Advisory Service for Rare NeuromuscularDiseases Muscle Immunoanalysis Unit, Newcastle upon Tyne, UnitedKingdom

  Consultant Clinical Scientist and Head of Muscle ImmunoanalysisUnit

  Aaron Beedle, Ph.D. (2003-2007)

  SUNY Binghamton University, Department of PharmaceuticalSciences, Binghamton, NY

  Vice-Chair and Associate Professor

  Daniel Beltrán, Ph.D. (2004-2013)

  Invitae Research Institute, San Francisco, CA Lead of MetabolicOperations

  Oxana Beskrovanya-Ibraghimov, Ph.D. (1990-1994)

  Dyne Therapeutics, Waltham, MA Senior Vice President, Head ofResearch

  Gloria Biddlecome, Ph.D. (1997-1999)

  Summer Stream Homes, LLC, Bakersfield, CA Self-employed

  Chien-Chang Chen, Ph.D. (1998-2004)

  Academia Sinica, Institute of Biomedical Sciences, Taipei,Taiwan

  Director, Department of International Affairs and ResearchFellow

  Ronald Cohn, M.D. (1998-2001)

  University of Toronto, Division of Clinical and MetabolicGenetics, Center for Genetic Medicine, The Hospital for SickChildren, Toronto, Canada

  President & CEO of The Hospital for Sick Children

  Ramon Coral-Vazquez, Ph.D. (1996-1999)

  Escuela Superior de Medicina, Intituto Politenico Nacional,Mexico City, Mexico

  Senior Researcher

  Rachelle Crosbie Watson, Ph.D. (1995-1999)

  UCLA, Department of Integrative Biology and Physiology, LosAngeles, CA

  Professor and Chair, Department of Integrative Biology andPhysiology

  Jessica de Greef, Ph.D. (2010-2015)

  Department of Human Genetics, Leiden University Medical Center,The Netherlands

  Senior Researcher

  Michel de Waard, Ph.D. (1991-1995)

  Institute of Thorax, Nantes, France Group Leader

  Franck Duclos, Ph.D. (1994-1998)

  Bristol-Myers Squibb Pharmaceutical Research Institute,Pennington, NJ

  Principal Scientist

• 15

  Madeleine Durbeej-Hjalt, Ph.D. (1997- 2001)

  Lund University, Department of Experimental Medical Science,Lund, Sweden

  Professor

  Toru Egashira, M.D./Ph.D. (2014-2019)

  Keio University School of Medicine, Department of Cardiology,Tokyo, Japan

  Assistant Professor

  James M. Ervasti, Ph.D. (1989-1992)

  University of Minnesota, Department of Biochemistry, MolecularBiology and Biophysics; Paul and Sheila Wellstone MuscularDystrophy Center, Minneapolis, MN

  Professor; Research Director

  Ricardo Felix, M.D./Ph.D. (1995-1998)

  Center for Research and Advanced Studies of the NationalPolytechnic, Department of Cell Biology, Mexico City, Mexico

  Professor

  Elena Gertsen, M.D./Ph.D. (2005-2007)

  East Tennessee State University, Department of Pathology,Johnson City, TN

  Clinical Assistant Professor

  Matthew Goddeeris, Ph.D. (2007-2014)

  Eloxx Pharmaceuticals, Waltham, MA Vice President, Research

  Severine Groh, Ph.D. (2001-2007)

  Delta State University, Division of Biological and PhysicalSciences, Cleveland, MS

  Associate Professor

  Renzhi Han, Ph.D. (2003 - 2009)

  Ohio State University, Wexner Medical Center, Columbus, OH

  Associate Professor

  Yuji Hara, Ph.D. (2005-2012)

  Graduate School of Engineering, Kyoto University, Department ofSynthetic Chemistry and Biological Chemistry, Kyoto, Japan

  Associate Professor

  Michael Henry, Ph.D. (1995-1999)

  University of Iowa, Department of Molecular Physiology andBiophysics, Iowa City, IA

  Professor, Deputy Director for Research, Holden ComprehensiveCancer Center

  Kathleen Holt, Ph.D. (1995-2000)

  Locus Biosciences, Inc., Morrisville, NC Senior Director,Eukaryotic Research

  Toshiaki Imagawa, Ph.D. (1985-1989)

  Hokkaido University, Graduate School of Science, Division ofChemistry, Biochemistry, Sapporo, Japan

  Associate Professor

  Kei-ichiro Inamori, Ph.D. (2006-2013)

  Institute of Molecular Biomembrane and Glycobiology, TohokuMedical and Pharmaceutical University, Sendai, Miyagi, Japan

  Associate Professor

  Daniel Jung, Ph.D. (1993-1996)

  Laval University, Hema-Quebec Research & Development,Quebec, Canada

  Associate Professor

  Motoi Kanagawa, Ph.D. (2001-2005)

  Ehime University Graduate School of Medicine, Department ofMolecular Cardiovascular Biology and Pharmacology, Ehime, Japan

  Professor

  Yvonne Kobayashi, Ph.D. (2000-2004)

  Eli Lilly & Company, Indianapolis, IN Senior Director,Emerging Technology & Innovation

• 16

  Kazuhiro Kobuke (2003 - 2009)

  Kandai University Faculty of Medicine, Department ofCardiovascular Medicine, Osaka, Japan

  Instructor

  Hajime Kusano, Ph.D. (2000-2005)

  Business Development & Licensing, Tokyo, Japan

  Manager

  Connie Lebakken, Ph.D. (1997-2001)

  Stem Pharm, Inc., Madison, WI President and Chief OperatingOfficer

  Jennifer Levy, Ph.D. (2008-2016)

  Coalition to Cure Calpain 3, Bryn Mawr, PA ScientificDirector

  John Lueck, Ph.D. (2008-2014)

  University of Rochester Medical Center, Department ofPharmacology and Physiology, Rochester, NY

  Assistant Professor

  Kiichiro Matsumura, M.D. (1990-1993)

  Teikyo University Medical School, Department of Neurology,Tokyo, Japan

  Professor

  Daniel Michele, Ph.D. (2000-2004)

  University of Michigan, Department of Molecular and IntegrativePhysiology, Ann Arbor, MI

  Professor and Graduate Program Director

  Kay Ohlendieck, Ph.D. (1989-1991)

  National University of Ireland, Department of Biology, Maynooth,County Kildare, Ireland

  Professor and Chair

  Jan Parys, Ph.D. (1990-1992)

  University of Leuven, Department of Cellular and MolecularMedicine, Leuven, Belgium

  Professor and Head

  Federica Piccolo, Ph.D. (1998-2002)

  Guido Berlucchi Foundation Brescia, Italy

  Funding Programme Manager

  Erik Rader, Ph.D. (2006-2012)

  National Institute for Occupational Safety and Health, Centersfor Disease Control and Prevention, Morgantown, WV

  Associate Service Fellow

  Steve Roberds, Ph.D. (1992-1995)

  Tuberous Sclerosis Alliance Silver Spring, MD

  Chief Scientific Officer

  Fumiaki Saito, M.D./Ph.D. (1999-2002)

  Teikyo University School of Medicine, Department of Neurology,Tokyo, Japan

  Associate Professor

  Yoshiaki Saito, M.D./Ph.D. (2003-2004)

  National Center Hospital of Neurology and Psychiatry, Departmentof Child Neurology, Tokyo, Japan

  Chief of Inpatient Ward

  Junshi Sakamoto, Ph.D. (1989-1991)

  Kyushu Institute of Technology, Department of Bioscience andBioinformatics, f*ckuoka, Japan

  Professor

  Jakob Satz, Ph.D. (2007-2009)

  Jackson Laboratories, Bar Harbor, ME Postdoctoral Fellow

• 17

  Victoria E. Scott, Ph.D. (1994-1996)

  Abbott Laboratories, Abbott Park, IL Principal ResearchScientist

  Volker Straub, M.D./Ph.D. (1995-1998)

  University of Newcastle upon Tyne, The John Walton MuscularDystrophy Research Centre Institute of Human Genetics, Tyne, UnitedKingdom

  Director and Professor

  Yoshihide Sunada, M.D./Ph.D. (1993-1996)

  Kawasaki Medical School, Department of Neurology, Okayama,Japan

  Vice Dean and Professor

  Barry Timms, M.D./Ph.D. (1985-1988)

  University of South Dakota, Sanford School of Medicine, Divisionof Basic Biomedical Sciences, Vermillion, SD

  Professor

  Rolf Turk, Ph.D. (2005-2014)

  Integrated DNA Technologies, Molecular Genetics Division,Coralville, IA

  Research Scientist I

  Tobias Willer, Ph.D. (2004-2013)

  Amicus Therapeutics, Philadelphia, PA Principal Investigator

  Derrick Witcher, Ph.D. (1991-1995)

  Lilly Research Laboratory Indianapolis, IN

  Senior Research Advisor

  Hiroki Yamada, M.D. (1996-1999)

  Tokyo Metropolitan Hiroo Hospital, Division of Neurology, Tokyo,Japan

  Division Chief

  Takahiro Yonekawa, M.D./Ph.D. (2014-2018)

  Mie University Graduate School of Medicine, Department ofPediatrics, Mie, Japan

  Takako Yoshida-Moriguchi (2003-2008)

  Sigilon Therapeutics, Inc., Cambridge, MA Director, MetabolicDiseases

  Co-Op Exchange Students

  Name Dates in

  Laboratory Post-Graduate Education Current Position

  Emma Hiscutt (University of Bath)

  June 1997-August 1997

  M.D., University of Oxford, UK Dermatologist, Private Practice,Victoria, Australia

  Sara Trewick (University of Bath)

  June 1997-September 1997

  Ph.D. Cancer Research UK – Clare Hall Laboratories, London,UK

  Senior Research Scientist, TPP Global Development, Ltd.,Edinburgh, UK

  Anne Mullen Grey (McMaster University)

  May 2002-August 2002

  Ph.D. Pharmacology and Toxicology, University of Toronto,Toronto, Ontario, Canada

  Medical Student, University of Toronto Faculty of Medicine,Toronto, Ontario, Canada

• 18

  Chris McLaughlin (McMaster University)

  May 2002-December 2002

  Ph.D., Cellular and Molecular Medicine, University of Ottawa,Ontario, Canada M.D., McMaster University, Ontario, Canada

  Resident, Department of Ophthalmology, McMaster University,Ontario, Canada

  Robert Svensson (University of Bath)

  August 2002-August 2003

  Ph.D., Molecular Physiology and Biophysics, University of Iowa,Iowa City, IA

  Senior Scientist, Nimbus Therapeutics, Cambridge, MA

  Daniel Nicholson (University of Bath)

  August 2003-July 2004

  M.S., Molecular and Cellular Biology, University of Bath, Bath,UK M.S., History and Philosophy of Science, University of Leeds,Leeds, UK Ph.D., Philosophy, University of Exeter, Exeter, UK

  Research Fellow, Centre for the Study of Life Sciences (Egenis),University of Exeter, Exeter, UK

  Jeeyoung Oh (Ewha Woman’s University Mokdong Hospital)

  September 2003-August 2004

  Department of Neurology, Konkuk University School of Medicine,Seoul, South Korea

  Stephane Vassilopoulos (Joseph Fourier University)

  February 2005-August 2005

  Ph.D., Biochemistry and Cell Biology, University Joseph Fourier,Grenoble, France

  Therapie des maladies du muscle strie, Institut de Myologie,INSERM, Paris, France

  Viviane Muniz (Universidad de Santo Amaro)

  March 2006-February 2007

  Ph.D. Dept. of Molecular and Cellular Biology, University ofIowa, Iowa City, IA

  Postdoctoral Research Scholar, Department of Pharmacology,University of Iowa, Iowa City, IA

  Kathryn ‘Conley’ Flynn (University of Iowa)

  September 2011-January 2013

  M.Ed. Dept. of Teaching and Learning, Vanderbilt University,Nashville, TN (in progress)

  Science Teacher, Cherry Creek High School, Green Village, CO

  Post-Baccalaureate Students

  Name Dates in

  Laboratory Education Current Position

  Nicolette Johnson August 2014-May 2015

  B.S. Biomedical Engineering University of Pennsylvania,M.D./Ph.D. program

  Raul O’campo Landa May 2015- May 2016

  B.S. Human Physiology University of Iowa, M.D. program

  Adam Mackey January 2016- May 2017

  B.S. Biology Columbia University, Lab Manager and ResearchAssistant, Dr. Adolfo Ferrando’s Laboratory

• 19

  Megan Devereaux

  December 2016- June 2017

  B.S. Human Physiology Kirkwood Community College, Dental Hygieneprogram; University of Iowa, Campbell Laboratory, ResearchAssistant

  Wellstone Education Programs (2005 – present) The WellstoneMuscular Dystrophy Cooperative Research Center (MDCRC) has majorresearch training and education missions. It supports two MedicalStudent Fellowships, a Postdoctoral Fellowship, aPost-Baccalaureate Research Internship, an Undergraduate ResearchFellowship, and a two-day conference at which patients and theiradvocates are educated about muscular dystrophy research. Themedical and postdoctoral fellows and the intern are mentored byboth Drs. Campbell and Mathews (Pediatric Neurology), and theundergraduate fellow is mentored by one or the other. Theeducational efforts of the Center are vital because there is anurgent need for basic scientists and clinicians who can partner todevelop and test muscular dystrophy therapies. Wellstone MedicalStudent Fellowship The goal of the Medical Student Fellowship is totrain the next generation of neurologists in translational medicinerelated to muscular dystrophy. This full-time fellowship enablestwo medical students per year to participate in all aspects of theCenter, including: care of muscular dystrophy patients in theneuromuscular disease clinics; clinical evaluation of patientsparticipating in Project 2, under the supervision of Dr. Mathews;evaluation of muscle biopsies with Dr. Steven Moore(Neuropathology); and study of patient cells in Dr. Campbell'slaboratory. In addition, these students present their findings frominteresting cases at the Neuromuscular Disease Conference once amonth. Wellstone Postdoctoral Research Fellowships The PostdoctoralResearch Fellowship trains scientists in the basic research ofmuscular dystrophy, by providing a PhD, MD, or MD/PhD graduate withan intensive research experience in Dr. Campbell’s laboratory. Thisexperience is complemented by observation of patient care in aclinical setting, enhancing the fellow’s understanding andappreciation of the clinical side of translational medicine.Wellstone Post-Baccalaureate Research Internship and UndergraduateResearch Fellowship The Post-Baccalaureate Research Internship isdesigned to encourage recent college graduates interested inpursuing graduate degrees to move into translational science byproviding a one-year intensive research experience in the Centerbefore s/he enters graduate school. The Undergraduate ResearchFellowship has a similar purpose, but is awarded to students whoare still enrolled at the University of Iowa; these individualswork closely with a postdoctoral fellow in the Center. WellstoneFamily Conference The Center has a strong tradition of involvingpatients and patient advocates by hosting a two-day conference andtours of its laboratories for patients and their families. The goalof the conference is to educate the patients about ongoingtranslational medicine in the MDCRC, and to provide a forum wherethey can ask questions concerning muscular dystrophy research. Thecurrent fellows and intern all participate in this conference.Through these activities, the Center is accelerating the educationmission of the MDCRC, and providing a vibrant training environmentfor clinician scientists. Departmental Chair Activities (2002 –present) Overview The Department of Molecular Physiology andBiophysics of the Roy J. and Lucille A. Carver College of Medicineis an outstanding basic science department that makes majorcontributions to the college’s three-part mission of teaching,research and service. The department is nationally andinternationally recognized for its strength and accomplishments inresearch, and is renowned for its exceptional contributions tomedical school teaching. The Department of Molecular Physiology andBiophysics is comprised of a highly interactive, intellectuallystimulating and productive faculty of scientists and educators. Atpresent, the department has 18 research faculty and one full-timeteaching faculty member. Faculty are recruited to the departmentfor their independent basic science research programs; however,most faculty have a component of translational medicine andparticipate in strong clinical collaborations. The department has astrong commitment to diversity, which is evidenced by its twofemale faculty members, one African American faculty member andthree members of Asian and Pacific

• 20

  Islander descent. All faculty members lead active and productiveresearch programs that are supported by external funding. Wecurrently have 11 faculty that average over 63% salary support fromgrants and/or teaching. Faculty Recruitment as DepartmentalChair

  Name and Degree Year Recruited Previous Institution (PostdocAdvisor) Rainbo Hultman, Ph.D. 2019 Duke University (Patrick Casey)Ted (Edwin) Abel, Ph.D. 2017 University of Pennsylvania (EricKandel) Julien Sebag, Ph.D. 2013 Vanderbilt University (Roger Cone)Janice Robertson, Ph.D. 2013 Brandeis University (ChristopherMiller) Christopher Ahern, Ph.D. 2012 University of BritishColumbia (Richard Horn) Amy Lee, Ph.D. 2008 Emory University(William Catterall) Mike Wright, Ph.D. 2008 University ofCalifornia, Davis (Ruedi Aebersold ) Charles Harata, Ph.D. 2007Stanford University (Richard Tsien) Alessio Accardi, Ph.D. 2007Brandeis University (Christopher Miller) Michael Henry, Ph.D. 2003Millenium Pharmaceuticals, Inc. (Kevin Campbell) Michael Anderson,Ph.D. 2003 The Jackson Laboratory (Simon John)

  Faculty Recruitment as Search Committee Chair

  Name and Degree Year Recruited Current Position Jeffrey Pessin,Ph.D. 1983 Diabetes Center Director, Albert Einstein Bruce Bean,Ph.D. 1983 Professor, Harvard Medical School, Boston, MA HollisCline, Ph.D. 1990 Professor, The Scripps Research Institute RobertoMalinow, Ph.D. 1990 Professor, Section of Neurobiology, UCSDToshinori Hoshi, Ph.D. 1992 Professor, Department of Physiology,Univ. Penn Sarah England, Ph.D. 1997 Professor, WashingtonUniversity, St. Louis, MO

  Graduate Student Education

  • Established the Molecular Physiology and Biophysics GraduateStudent Symposium • Established the Ramon D. Buckley GraduateStudent Scholarship • Established Paper of the Year award for adepartmental graduate student with an outstanding publication

  Postdoctoral Fellow Education

  • Established the Departmental Postdoc Career Enhancement group• Developed a postdoctoral seminar mentoring program by facultymembers • Established the Peter A. Getting Postdoctoral ScholarAward

  Undergraduate Education

  • Developed and implemented a training program for undergraduatestudents (Coop Exchange Program). • Developed and implemented aninternship program for recent graduates (Post-BaccalaureateProgram).

  Departmental Chair Talks

  DEO Department Review/SWOT Meeting with Dean Schwinn andadministration of the Carver College of Medicine, “DepartmentReview” University of Iowa, Iowa City, Iowa, 2015.

• 21

  Presentation at “DEO Metrics, Spring 2010” University of IowaDepartment of Molecular Physiology & Biophysics FacultyMeeting, Iowa City, Iowa, May 11, 2010.

  DEO Department Review/SWOT Meeting with Dean Rothman & CCOMAdministration, “SWOT Analysis and Department

  Review” University of Iowa, Iowa City, Iowa, February 16, 2009.“The Interview” presentation to University of Iowa Department ofMolecular Physiology & Biophysics Postdoc Career

  Enhancement Group, Iowa City, Iowa, November 10, 2008. “Applyingand Preparing for Faculty Positions” presentation at the Universityof Iowa Department of Molecular Physiology &

  Biophysics Postdoc Professional Development Series, Iowa City,Iowa, November 13, 2006. “CV and Resume Preparation” presentationat the University of Iowa Department of Molecular Physiology &Biophysics

  Postdoc Professional Development Series, Iowa City, Iowa, August14, 2006. “Physiology and Biophysics” presentation at theUniversity of Iowa Carver College of Medicine (CCOM) Executive

  Committee Meeting, Iowa City, Iowa, September 12, 2005.“Physiology and Biophysics” orientation presentation to Universityof Iowa Biosciences Program Students as Professor and

  Interim Head, Iowa City, Iowa August 19, 2004. FinancialResource Support (Grants and Contracts) Current Grants

  Title Period Amount

  Investigator, Howard Hughes Medical Institute (Renewed10/19)

  10/01/89-11/30/24

  NIH/NINDS 5 U54 NS053672-11 Senator Paul D. Wellstone MuscularDystrophy Cooperative Research Center “Therapeutic Strategies forCongenital and Limb-Girdle Muscular Dystrophies” (PI: KPCampbell)

  06/08/05-06/30/20 $1,017,766

  Recent Past Grants

  Title

  Period Amount

  Muscular Dystrophy Association 238219 “Protein O-mannosylation:Classification of New Players in Muscular Dystrophy” (PI: KPCampbell)

  08/01/12-07/31/15 $113,637/year

  Muscular Dystrophy Association “Pathways and Consequences ofNon-dysferlin Mediated Membrane Repair” (PI: JenniferLevy-Keiser)

  8/01/11-07/31/14 $60,000/year

  Muscular Dystrophy Associate “Pathophysiology of Muscle Weaknessand Wasting in Myotonic Dystrophy” (PI: John Lueck)

  02/01/11-01/31/14

  $60,000/year

• 22

  5 T32 HL 7121-37 Iowa Cardiovascular Center InstitutionalTraining Grant “Dystroglycan-dependent anchoring of dystrophinprevents muscular dystrophy” (PI: Rolf Turk)

  08/15/12-08/14/13 $58,000/year

  Muscular Dystrophy Association “Molecular Basis ofGlycosylation-Deficient Muscular Dystrophy” (PI: KP Campbell)

  01/01/10-12/31/12 $144,203/year

  Ruth L. Krischstein NRSA Fellowship “Mechanisms Required forDystroglycan Posttranslational Modification” (PI: M Goddeeris,Co-PI: KP Campbell)

  01/15/09-01/14/12 $57,094/year

  NIH/NINDS 1 RC2 NS069521-01 (GO Grant) “High-Throughput Genetic& Small-Molecule Screening for Therapeutic Modifiers” (PI: KPCampbell)

  09/30/09-08/31/11 $1,233,893

  Myotonic Dystrophy Fellowship “The Role of Sarcolemmal MembraneFidelity in DM Muscle Pathogenesis” (PI: J Lueck, Co-PI: KPCampbell)

  04/01/09-03/31/11 $50,000/year

  Cardiovascular Center Institutional Research Fellowship “Rolesof Dynamin 2 in Myofiber Organization and Centronuclear Myopathy”(PI: J Levy, Co-PI: KP Campbell)

  01/01/09-12/31/10 $47,429/year

  Muscular Dystrophy Association Research Development Grant “Roleof Muscle Development/Regeneration in the Pathology ofDystroglycanopathy” (PI: A Beedle, Co-PI: KP Campbell)

  01/01/09-12/31/10 $60,000/year

  Muscular Dystrophy Association Research Development Grant“Efficacy of LARGE as a Therapeutic Strategy for Limb-GirdleMuscular Dystrophy” (PI: EP Rader; Co-PI: KP Campbell)

  01/01/08-12/31/10 $45,000/year

  NIH/NIAMS 3 R01 AR051199-05S1 (R01 Supplement) “Therapeuticpotential of α-sarcoglycan in the treatment of limb-girdle musculardystrophy type 2D (LGMD-2D)” (PI: KP Campbell)

  09/23/09-09/22/10 $325,990

  NIH/NIAMS 5 R01 AR051199 “Therapeutic Potential of ε-sarcoglycanin the Treatment of LGMD Type 2D” (PI: KP Campbell)

  04/01/04-03/31/10 $218,366

• 23

  Physical Facilities Office and Laboratory – Carver BiomedicalResearch Building, 4283 CBRB, 2500 sq. ft. Current PersonnelSupervised

  Postdoctoral Fellows Previous University Start Date DegreeHidehiko Okuma Teikyo University 2016 M.D., Ph.D. Soumya JosephAustralian National University 2016 Ph.D. Jeffrey Hord TexasA&M University 2016 Ph.D. Tiandi Yang Imperial College London2017 Ph.D.

  Research Assistants Post-Baccalaureate Research InternsAdministrative Support Mary Anderson Megan Devereaux Jaeda HarmonKeith Garringer Amber Mower Sally Prouty Rachel Poe David VenzkeUndergraduate Lab Assistants Sarah Burns Anna Ford Mercedes JuelfsGraduate Students Carmin Martinez Ameya Walimbe (MSTP) ShellyMelton Saul O’campo Landa Ben Yeo

  Clinical and Translational Activities 1997-present WellstoneMuscular Dystrophy Cooperative Research Center Director: KevinCampbell

  Exploration of therapeutic strategies for the treatment ofvarious muscular dystrophies by enabling translational research onmuscular dystrophies and providing advanced diagnosticservices.

  1997-present Neuropathology Meeting Organizers: Kevin Campbell(Molecular Physiology & Biophysics), Katherine Mathews(Pediatrics and Neurology), Steven Moore (Pathology) Review anddiscussion of recent neuromuscular disease patients seen atUniversity of Iowa Hospitals and Clinics or muscle biopsies sent toneuropathology at the University of Iowa for analysis. * for a moredetailed description of the Neuromuscular Disease Group, please seeappendix XI 2000-2007 Limb-Girdle Muscular Dystrophy StudyCoordinating Center: Ohio State University

  PI: Jerry R. Mendell (Ohio State University) Co-PIs: StevenMoore, Kevin P. Campbell (University of Iowa) Members: KatherineMathews (University of Iowa), Robert C. Griggs (University ofRochester), Alan Pestronk (Washington University), Gerald Fenichel(Vanderbilt University), Hansel Stedmann (University ofPennsylvania) Aims: 1. Establish a registry of LGMD patients inNorth America with defined gene mutations, for purposes of

  determining the incidence and natural history of specificdisorders in this outbred population. 2. Establish a cohort of LGMDpatients with defined gene mutations to participate in clinicaltrial involving

  gene transfer. 3. Define appropriate end points for clinicalefficacy for clinical trials including gene transfer in LGMD.

• 24

  Invited Seminars (2004 – Present) 2004 New Directions in Biologyand Disease of Skeletal Muscle, San Diego, California

  University of Pennsylvania Children’s Hospital, Philadelphia,Pennsylvania Keystone Symposium on Molecular Biology and CardiacDisease, Keystone, Colorado Cincinnati Children’s Hospital MedicalCenter Rachford Lecture, Cincinnati, Ohio Ohio State UniversityResearch Day, Columbus, Ohio University of Washington Department ofBiochemistry, Seattle, Washington University of California, SanDiego, California American Academy of Neurology Plenary Session,Frontiers in Clinical Neuroscience-Beyond the Decade of

  the Brain, San Francisco, California University of Rochester,Rochester, New York George H. Bishop Lecture Series, WashingtonUniversity, St. Louis, Missouri Howard Hughes Medical InstituteScientific Meeting, Chevy Chase, Maryland Gordon ResearchConference on Basem*nt Membranes, Bristol, Rhode Island MuscularDystrophy Scientific Workshop Toward Therapeutics, Foundation toEradicate duch*enne, Inc., La

  Jolla, California 43rd Annual Iowa Branch American Associationfor Laboratory Animal Science, Iowa City, Iowa American Society forMatrix Biology, San Diego, California University of Iowa NeurologyGrand Rounds, Iowa City, Iowa 2005 European Neuro Muscular CentreInternational Workshop on Congenital Muscular Dystrophy, Naarden,The

  Netherlands Third Annual Neuromuscular Conference and EMGWorkshop, London Health Sciences Centre, London,

  Ontario, Canada University of Iowa Internal Medicine GrandRounds, Iowa City, Iowa University of Connecticut Health CenterCardiovascular Grand Rounds, Farmington, Connecticut InternationalCongress of Physiological Sciences, San Diego, CaliforniaUniversity of Columbia Colleen Giblin Lecture, New York, New YorkDuke CMB Symposium, Duke University, Durham, North Carolina MiniMedical School Program, University of Iowa, Iowa City, Iowa AFMScientific Congress on Myology, Nantes, France Johns HopkinsNeurology Grand Rounds, Johns Hopkins University, Baltimore,Maryland Yale Pharmacology Lecture, Yale University, New Haven,Connecticut Harvard Children’s Hospital Orthopedic ResearchSeminar, Boston, Massachusetts FASEB Summer Research Conference“Skeletal Muscle Satellite and Stem Cells,” Tucson, Arizona 26thAnnual David W. Smith Workshop on Malformations and Morphogenesis,The University of Iowa World Muscle Society Meeting, Iguassu Falls,Brazil Society for Glycobiology, Boston, Massachusetts ScrippsResearch Institute, San Diego, California 2006 Masters Class inMolecular Mechanisms of Disease Glycogenetics and NeuromuscularDiseases, Nijmegen

  School of Molecular Life Sciences (NCMLS), Nijmegen, TheNetherlands Harvard Cell Biology Seminar, Boston, MassachusettsNeuroscience Program Seminar, The University of Iowa, Iowa City,Iowa 79th Annual Japanese Pharmacological Society, Yokohama, JapanOsaka University Seminar, Osaka, Japan Department of MolecularBiology and Genetics Seminar, Johns Hopkins University, Baltimore,Maryland New Directions in Biology and Disease of Skeletal MuscleMeeting, Dallas, Texas Frontiers in Myogenesis Meeting, CallawayGardens, Pine Mountain, Georgia Department of Defense MilitaryHealth Research Forum, San Juan, Puerto Rico Genetics In-ServiceSpecial Presentation, The University of Iowa, Iowa City, IowaNeurosurgery Research Conference, The University of Iowa, IowaCity, Iowa XVI International Congress of Neuropathology, SanFrancisco, California HHMI Science Meeting. Janelia Farm ResearchCampus, Ashburn, Virginia UT Southwestern Grand Rounds, UTSouthwestern, Dallas, Texas Neuromuscular Plasticity Symposium,University of Florida, Gainesville, Florida 2007 KeystoneSymposium: Molecular Pathways in Cardiac Development and Disease,Breckenridge, Colorado Neurosciences Seminar Series, StanfordUniversity, Stanford, California Presidential Lecture, TheUniversity of Iowa, Iowa City, Iowa Mini Medical School, TheUniversity of Iowa, Iowa City, Iowa Medical College of WisconsinStudent Choice Lecture, Milwaukee, Wisconsin

• 25

  The 20th Anniversary of the DMD Gene Discovery: Impact on MuscleBiology, Disease and Therapy, Ottawa Neurology Grand Rounds, TheUniversity of Iowa, Iowa City, Iowa Cornell Biomedical Sciences,Neuroscience Program, and Institute of Cell and MolecularBiology

  Distinguished Lecture, Cornell University, Ithaca, New YorkGenzyme Seminar, Boston, Massachusetts Jain Foundation First AnnualDysferlin Conference, Bermuda HHMI Scientific Meeting-MolecularTransport and Trafficking, Ashburn, Virginia Faculty of Medicine:Perceptions of the Cell, Vancouver, British Columbia, Canada BrainResearch Centre, Vancouver, British Columbia, Canada University ofMichigan Symposium, Ann Arbor, Michigan World Muscle Society,Giardini Naxos, Italy 2008 ENMC Workshop on CMD, Naarden, TheNetherlands Neuromuscular Disease Seminar, Leiden, The NetherlandsBanbury Center Meeting, Cold Spring Harbor, New York LoyolaUniversity White Lecture, Maywood, Illinois SGH 17th AnnualScientific Meeting, Singapore New Directions in Biology and Diseaseof Skeletal Muscle, New Orleans, Louisiana International Workshopfor Glycosylation Defects in Muscular Dystrophy, Charlotte, NorthCarolina Sloan-Kettering Cancer Center Seminar, New York, New YorkHarvard Medical School Grand Rounds, Boston, Massachusetts GordonResearch Conference on Basem*nt Membranes, Biddeford, Maine IowaCongenital Muscular Dystrophy Meeting, Iowa City, Iowa Society forGeneral Physiologists, Woods Hole, Massachusetts University ofKentucky Distinguished Speaker Series, Lexington, Kentucky 4thBanbury Conference on SMA: Taking on New Complexities in SMABiology, Cold Spring Harbor CFA Symposium, Philadelphia,Pennsylvania 2009 HHMI Science Meeting, Chevy Chase, Maryland TheScripps Research Institute Bernard Field Lecture, La Jolla,California Vanderbilt Discovery Lecture, Nashville, TennesseeColumbia University Making Muscle in the Embryo and Adult jointmeeting with Frontiers in Myogenesis,

  New York, New York March of Dimes Prize in Developmental BiologyAcceptance Lecture, Baltimore, Maryland Novartis Institutes forBioMedical Research, Inc., Cambridge, Massachusetts BostonBiomedical Research Institute (BBRI), Watertown, Massachusetts CMDTherapeutic Target Conference, Atlanta, Georgia Keynote Speaker,Society of General Physiologists, Woods Hole, Massachusetts Societyof Glycobiology, San Diego, California 49th American Society forCell Biology Annual Meeting, San Diego, California 2010 ENMCWorkshop on Dysferlinopathy, Naarden, The Netherlands UC SantaBarbara, Santa Barbara, California Loyola University Chicago,Chicago, Illinois Genzyme Corp., Framingham, MassachusettsUniversity of Georgia, Athens, Georgia The Ottawa Conference on NewDirections in Biology & Disease in Skeletal Muscle, Ottawa,Ontario,

  Canada University of Nebraska Medical Center, Omaha, NebraskaUniversity of Minnesota, Lillehei Heart Institute, Minneapolis,Minnesota University of Texas Health Science Center – Houston,Institute of Molecular Medicine, Houston, Texas XII InternationalCongress on Neuromuscular Diseases, Naples, Italy University ofWisconsin, Cardiovascular Research Conference, Madison, WisconsinAmerican Society of Matrix Biology meeting, Charleston, SouthCarolina University of Texas Southwestern, Dallas, Texas MuscularDystrophy Workshop, Charlotte, North Carolina Children’s NationalMedical Center, Washington, District of Columbia 2011 NGMBiopharmceuticals, Inc., San Francisco, California UC San Diego,San Diego, California Glycobiology Symposium, San Diego, California2nd Annual SBMRI Rare Disease Symposium, San Diego, California

• 26

  UC Davis, Davis, California UC San Francisco, GladstoneInstitute, San Francisco, California 1st Chinese conference ontranslational research in duch*enne muscular dystrophy, Guangzhou,China The Sanford-Burnham Medical Research Institute, La Jolla,California Nationwide Children’s Hospital, The Ohio StateUniversity, Columbus, Ohio AANP Annual Meeting, PresidentialSymposium, Seattle, Washington Gordon Research Conference onCollagen, New London, New Hampshire Consortium for FunctionalGlycomics PI Meeting, Bethesda, Maryland International Conferenceon Muscle Wasting 2011, Ascona, Switzerland Coalition to CureCalpain3 LGMD2A Workshop, Santa Monica, California Kurt EbnerDiscovery Lecture, University of Kansas Medical Center, KansasCity, Kansas ENMC Dystroglycan and Dystroglycanopathies Workshop,Naarden, The Netherlands 2012 Iowa State University, Ames, IowaCMD: Exploring the Role of Myomatrix, Reno, Nevada University ofNebraska-Lincoln, Lincoln, Nebraska Yeshiva University, EinsteinCollege of Medicine, Bronx, New York Frontiers in MyogenesisMeeting, New York, New York New Directions in Biology and Diseaseof Skeletal Muscle Conference, New Orleans, Louisiana InstitutPasteur, Paris, France Duke University, Durham, North CarolinaWorld Muscle Society Meeting, Perth, Australia Panel Discussion:Disease Pathogenesis, Wellstone Centers Meeting, Watertown,Massachusetts College of Medicine Dean’s Distinguished Lecture,University of Kentucky, Lexington, Kentucky Center for MuscleBiology Fall Retreat, University of Kentucky, Lexington, Kentucky2013 Glycobiology Research Conference, Ventura, CaliforniaGlycosylation Workshop, Charlotte, North Carolina ASBMB AnnualMeeting, Boston, Massachusetts HHMI Scientific Meeting, Ashburn,Virginia Johnson-Sokatch Lectureship, University of Oklahoma,Oklahoma City, Oklahoma Dept. of Biological Chemistry SeminarProgram, Johns Hopkins University, Baltimore, Maryland 55th AnnualMeeting of the Japanese Society of Child Neurology, Oita, JapanSegawa Neurological Clinic for Children Symposium, Tokyo, JapanJohn and Margaret Faulkner Lectureship, University of Michigan, AnnArbor, Michigan EMBO Workshop on Muscle Wasting, Ascona,Switzerland Cornell University Physiology Biophysics and SystemsBiology Seminar Series, New York, New York University of Georgia,Athens, Georgia 2014 Cincinnati Children’s Heart Institute SeminarSeries, Cincinnati, Ohio Pediatrics Frontiers in Research seminar,University of Iowa, Iowa City, Iowa Neurology Grand Rounds,University of California Los Angeles, Los Angeles, CaliforniaBaylor College of Medicine Seminar, Baylor University, Houston,Texas Presentation to the Carver Trust, University of Iowa, IowaCity, Iowa Neurogenetics Symposium, University of Iowa, Iowa City,Iowa Texas A&M University Neuroscience Seminar, Texas A&MUniversity, College Station, Texas Duke University BiochemistrySeminar, Duke University, Durham, North Carolina

  2015 Frontiers in Biomedical Research Symposium, ScrippsResearch Institute, Indian Wells, California Muscular DystrophyAssociation Scientific Conference, Washington, DC Biochemistry,Biophysics and Molecular Biology Seminar, Iowa State University,Ames, Iowa Alexion Muscular Dystrophy Symposium, Cheshire,Connecticut Physics Education Group Meeting, Washington, DCWorkshop for Glycosylation Defects in Muscular Dystrophy,Charlotte, North Carolina National Academy of Sciences Meeting,Washington, DC

• 27

  Pfizer Frontiers in Human Disease Symposium, New York, New YorkUniversity of Minnesota Biochemistry Seminar, Minneapolis,Minnesota Translational Biology and Molecular Medicine Bench toBedside Seminar, Baylor University, Houston, Texas ENMC Workshop onAnimal Models for Congenital Muscular Dystrophies, Naarden, TheNetherlands Parent Project Muscular Dystrophy Meeting, Washington,DC UPS Workshop on Glycosylation Analysis for Biopharmaceuticals,Rockville, Maryland Society of General Physiologists Symposium,Woods Hole, Massachusetts Muscle Wasting Meeting, Ascona,Switzerland Ottawa Conference on Neuromuscular Biology, Disease,and Therapy, Ottawa, Canada Wellstone Centers Network Meeting,Seattle, Washington University of Virginia Seminar,Charlottesville, Virginia Howard Hughes Medical Scientific Meeting,Chevy Chase, Maryland Society for Glycobiology Meeting, SanFrancisco, California Vanderbilt Biomedical Science Advisory BoardMeeting, Nashville, Tennessee ARMGO Meeting, New York City, NewYork

  2016 ENMC Workshop on f*ckutin Related Protein – RelatedMyopathies, Naarden, The Netherlands University of California, SanDiego Seminar, San Diego, California Oregon State UniversitySeminar, Corvallis, Oregon Howard Hughes Medical InstituteScientific Meeting, Chevy Chase, Maryland National Academy ofSciences Meeting, Washington, DC Spinal Muscular AtrophyFoundation, Muscle Advisory Board Meeting, New York City, New YorkVanderbilt University Seminar, Nashville, Tennessee ENMC Workshopon Dystroglycan and the Dystroglycanopathies, Naarden, TheNetherlands Society for Muscle Biology Meeting, Asilomar,California Genzyme Scientific Advisory Board Meeting, Framingham,Massachusetts 10th International Symposium on Glycosyltransferases,Toronto, Canada Parent Project Muscular Dystrophy Annual ConnectConference, Orlando, Florida New Directions in Biology and Diseaseof Skeletal Muscle Conference, Orlando, Florida Salk Meeting onPost-translational Regulation of Cell Signaling, La Jolla,California BioMed Central Editors’ Conference, New York, New YorkUniversity of Maine GSBSE Seminar, Orono, Maine University of IowaNeuromuscular-Neurogenetics Symposium, Iowa City, IowaInternational Congress of The World Muscle Society, Granada, SpainAmerican Society for Matrix Biology Meeting, St. Petersburg,Florida Muscular Dystrophy Coordinating Committee Meeting (NIH),Bethesda, Maryland Vanderbilt University Biomedical ScienceAdvisory Board Meeting, Nashville, Tennessee University ofMinnesota, Marzolf Symposium, Minneapolis, Minnesota

  2017 Advances in Skeletal Muscle Biology in Health & DiseaseConference, Gainesville, Florida UCLA Clinical and TranslationalScience Institute Seminar Series, Los Angeles, CaliforniaInternational Workshop for Glycosylation Defects in MuscularDystrophy, Charlotte, North Carolina George Karpati Lecture, McGillUniversity, Montreal Canada FASEB Meeting - From Unfolded Proteinsin the ER to Disease Conference, Saxton’s River, Vermont CMDScience & Family Conference, Washington, DC University ofGeorgia Center for Molecular Medicine Symposium, Athens, GeorgiaUniversity of Iowa Neuromuscular-Neurogenetics Symposium, IowaCity, Iowa Society of Glycobiology Innovators Award Lecture,Portland, Oregon Howard Hughes Medical Institute ScientificMeeting, Chevy Chase, Maryland UT Southwestern, Fouad A. and ValImm Bashour Distinguished Lectureship in Physiology, Dallas, TexasAmerican Society for Cell Biology/European Molecular BiologyOrganization Meeting, Philadelphia,

  Pennsylvania Vanderbilt University Biomedical Science AdvisoryBoard Meeting, Nashville, Tennessee Tufts University, Sakler Schoolof Graduate Biomedical Sciences Seminar, Medford, Massachusetts

• 28

  2018 Sanford Burnham Prebys Rare Disease Day Symposium &Congenital Disorders of Glycosylation Family Conference, San Diego,California

  University of Vermont Pharmacology Seminar, Burlington, VermontKyoto University, Katsura Campus Seminar, Kyoto Japan GraduateSchool of Medicine Kobe University Seminar, Kobe, Japan JapanMuscle Society Meeting, Kurashiki, Japan University of IowaNeuromuscular-Neurogenetics Symposium, Iowa City, Iowa MuscleWasting Meeting, Ascona, Switzerland Harvard GlycoscienceSymposium, Boston, Massachusetts 2019 International Workshop forGlycosylation Defects in Muscular Dystrophies, Charlotte, NorthCarolina

  100 Years of Neurology at the University of Iowa CentennialSymposium, Iowa City, Iowa University of IowaNeuromuscular-Neurogenetics Symposium, Iowa City, Iowa 5th OttawaInternational Conference on Neuromuscular Disease & Biology,Ottawa Canada

  University of Iowa First-Generation Student Awards andRecognition Ceremony, Iowa City, Iowa Wellstone Centers NetworkMeeting, Rochester, New York

  2020 University of California, San Diego Cellular &Molecular Medicine Seminar, San Diego, CA San Diego GlycobiologySymposium, San Diego, CA Regeneron Seminar Series, Tarrytown, NYASBMB Herbert Tabor Research Award & Lectureship, San Diego, CAAmerican College of Rheumatology Pediatric Rheumatology Symposium,New Orleans, LA Howard Hughes Medical Institute Scientific Meeting,Ashburn, VA Amicus Therapeutics Seminar, Philadelphia, PA 12thInternational GlycoT Conference, Boston, MA ENMC Workshop,Hoofddorp, The Netherlands Tamio Yamakawa Award Lecture, Tokyo,Japan

  Patents

  1. Title: Immunogen Conjugates and the Use Thereof in aDihydropyridine Assay

  Inventor: Kevin P. Campbell Patent No: 4,784,955 Patent Issue:November 15, 1988

  2. Title: Dihydropyridine Receptor and Antibodies TheretoInventors: Kevin P. Campbell, Toshiaki Imagawa and Albert T. LeungPatent No: 4,912,202 Patent Issue: March 27, 1990

  3. Title: Measuring Non-Dystrophin Proteins and DiagnosingMuscular Dystrophy Inventors: Kevin P. Campbell, James M. Ervasti,Kay Ohlendieck, Mitchell G. Gaver and Steven D. Kahl Patent No:5,187,063 Patent Issue: February 16, 1993

  4. Title: Diagnosing Malignant Hyperthermia Susceptibility byDetection of Abnormal Proteolytic Enzyme Digestion Fragments of theRyanodine Receptor Inventors: Kevin P. Campbell, C. MichaelKnudson, Steven D. Kahl, Charles F. Louis and James R. MickelsonPatent No: 5,242,801 Patent Issue: September 7, 1993

  5. Title: Nucleic Acids Encoding Dystrophin-Associated ProteinsInventors: Kevin P. Campbell, Oxana Ibraghimov-Beskrovnaya, JamesM. Ervasti and Cynthia J. Leveille Patent No: 5,260,209 PatentIssue: November 9, 1993

  6. Title: Diagnosis of Autosomal Muscular Dystrophy Inventors:Kevin P. Campbell and Kiichiro Matsumura Patent No: 5,308,752Patent Issue: May 3, 1994

  7. Title: Calcium Channel Compositions and Methods

• 29

  Inventors: Scott Jay, Steven B. Ellis, Michael M. Harpold andKevin P. Campbell Patent No: 5,386,025 Patent Issue: January 31,1995

  8. Title: Measuring Non-Dystrophin Proteins and DiagnosingMuscular Dystrophy Inventors: Kevin P. Campbell, James M. Ervasti,Kay Ohlendieck, Mitchell G. Gaver and Steven D. Kahl Patent No:5,413,910 Patent Issue: May 9, 1995

  9. Title: Method for Screening for Cardiomyopathy Inventors:Kevin P. Campbell Patent No: 5,418,139 Patent Issue: May 23,1995

  10. Title: Purified, Native Dystrophin Inventors: Kevin P.Campbell, Steven D. Kahl and James M. Ervasti Patent No: 5,430,129Patent Issue: July 4, 1995

  11. Title: Nucleic Acid Encoding Dystrophin-Associated ProteinInventors: Kevin P. Campbell, Steven L. Roberds and Richard D.Anderson Patent No: 5,449,616 Patent Issue: September 12, 1995

  12. Title: Diagnosing Malignant Hyperthermia Susceptibility byDetection of Abnormal Proteolytic Enzyme Digestion Fragments of theRyanodine Receptor Inventors: Kevin P. Campbell, C. MichaelKnudson, Steven D. Kahl, Charles F. Louis and James R. MickelsonPatent No: 5,462,857 Patent Issue: October 31, 1995

  13. Title: Immunogenic Ryanodine Derivative and Related UsesInventors: Kevin P. Campbell, Derrick R. Witcher, Peter McPherson,Steven D. Kahl, John D. Windass, Terence Lewis and Philip BentleyPatent No: 5,492,839 Patent Issue: February 20, 1996

  14. Title: β-Sarcoglycan Nucleic Acid Sequence, DeleteriousMutations and Applications Inventors: Kevin P. Campbell, LelandLim, Franck Duclos, Yoshihide Sunada, Jacques Beckmann, OdileBroux, Fernando M. S. Tomé, Michel Fardeau and Charles E. JacksonPatent No: 5,672,694 Patent Issue: September 30, 1997

  15. Title: Polyclonal and Monoclonal Antibodies Against a 43 kDaDystrophin Associated Protein Inventors: Kevin P. Campbell, OxanaB. Ibraghimov, James M. Ervasti and Cynthia J. Leveille Patent No:5,686,073 Patent Issue: November 11, 1997

  16. Title: Recombinant Production of Mammalian Calcium ChannelGamma Subunits Inventors: Scott D. Jay, Steven B. Ellis, Michael M.Harpold and Kevin P. Campbell Patent No: 5,726,035 Patent Issue:March 10, 1998

  17. Title: Methods for Detecting Primary AdhalinopathyInventors: Kevin P. Campbell, Steven Roberds, Yoshihide Sunada,Federica Piccolo, Marc Jeanpierre and Jean-Claude Kaplan Patent No:5,733,732 Patent Issue: March 31, 1998

  18. Title: δ-Sarcoglycan Nucleic Acid Sequences Inventor: KevinP. Campbell, Daniel Jung, Franck Duclos, Volker Straub and JohnMcPherson Patent No: 5,837,537 Patent Issue: November 17, 1998

  19. Title: Merosin Deficiency-Type Congenital Muscular DystrophyInventors: Kevin P. Campbell, Yoshihide Sunada, Fernando M.S. Tomé,Michel Fardeau Patent No: 5,863,743 Patent Issue: January 26,1999

• 30

  20. Title: Arenavirus Receptor and Methods of Use. Inventors:Kevin P. Campbell, Michael Henry, Hiroki Yamada, Roger Williamson,Wei Cao, Michael Oldstone

  Patent No: 6,083,911 Patent Issue: July 4, 2000 21. Title:Method for Aiding the Diagnosis of In-Frame Deletion TypeCongenital Muscular Dystrophy

  Inventors: Kevin P. Campbell, Valérie Allamand, YoshihideSunada, Voker Straub, Mustafa Salih Patent No: 6,136,546 PatentIssue: October 24, 2000 22. Title: Pathogenesis ofCardiomyopathy

  Inventors: Kevin P. Campbell, Ramon Coral, Ronald Cohn, RogerWilliamson and Madeleine Durbeej Patent No: 6,201,168 B1 PatentIssue: March 13, 2001 23. Title: Sarcospan-Deficient Mouse as aModel for Clinical Disorders Associated with SarcospanMutations

  Inventors: Kevin P. Campbell, Connie Lebakken, Rachelle Crosbie,Roger Williamson Patent No: 6,207,878 B1 Patent Issue: March 27,2001 24. Title: δ-Sarcoglycan Nucleic Acid Sequences, Amino AcidSequences and Applications Inventors: Kevin P. Campbell, DanielJung, Franck Duclos, Volker Straub and John McPherson Patent No:6,211,340 B1 Patent Issue: April 3, 2001 25. Title: GeneReplacement Therapy for Muscular Dystrophy

  Inventors: Kathleen H. Holt, Franck Duclos, Leland E. Lim,Volker Straub, Beverly Davidson, Roger Williamson and Kevin P.Campbell

  Patent No: 6,262,035 B1 Patent Issue: July 17, 2001 26. Title:Receptor for Mycobacterium Leprae and Methods of Use Thereof

  Inventors: Anura Rambukkana, Vincent A. Fischetti and Kevin P.Campbell Patent No: 6,331,405 B1 Patent Issue: December 18, 200127. Title: Genes Encoding Neuronal Voltage-Gated Calcium Channel γSubunits

  Inventors: Verity A. Letts, Wayne N. Frankel, Kevin P. Campbell,Ricardo Felix, Gloria Biddlecome Patent No: 6,365,337 B1 PatentIssue: April 2, 2002

  28. Title: Evaluation of Adenocarcinoma of the Prostate andBreast Using Anti-Dystroglycan Antibodies Inventors: Kevin P.Campbell, Michael Henry, Michael B. Cohen Patent No: 6,379,893 B1Patent Issue: April 30, 2002

  29. Title: Disruption of the Sarcoglycan-Sarcospan Complex inVascular Smooth Muscle: A Novel Mechanism in the

  Pathogenesis of Cardiomyopathy and Muscular Dystrophy.Inventors: Kevin P. Campbell, Roger Williamson, Ramon Coral, RonaldD. Cohn Patent Application: August 20, 1999

  30. Title: Increasing Functional Glycosylation of α-Dystroglycanin the Treatment of Muscle Degeneration. Inventors: Kevin P.Campbell and Rita Barresi

  Patent No: 8,119,766 B2 Patent Issue: February 21, 2012 31.Title: Inhibitors of Phosphodiesterase Type 5A for Treating orPreventing Muscle Disease or the Symptoms Thereof

  in a Patient. Inventors: Kevin P. Campbell, Yvonne Kobayashi,and Robert Crawford

  Patent No: 9,387,210 B2 Patent Issue: July 12, 2016

  32. Title: Inhibitors of Phosphodiesterase Type 5A for ReducingSkeletal Muscle Fatigue, Edema, and Damage in a Patient HavingMuscle Fatigue due to Increased Age of Exercise.

  Inventors: Kevin P. Campbell, Yvonne Kobayashi, and RobertCrawford Patent No: 9,943,518 B2 Patent Issue: April 17, 2018

• 31

  Bibliography Reviews, Book Chapters, and Editorials Campbell,K.P. and Tortorelli, P. A Study of Ferritin Using the MossbauerEffect. The Manhattan Scientist. 26, 50-53, 1973. Campbell, K.P.and Tortorelli, P. Application of Mossbauer Spectroscopy to theStudy of Ferritin. The Manhattan Scientist. 27, 4-10, 1974.Campbell, K.P. and Shamoo, A.E. Identification of Two IntrinsicProteins Uniquely Associated with the Terminal Cisternae of theSarcoplasmic Reticul

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